diff --git a/app/brave_generated_resources.grd b/app/brave_generated_resources.grd
index c6210567330..2042ad42a68 100644
--- a/app/brave_generated_resources.grd
+++ b/app/brave_generated_resources.grd
@@ -939,6 +939,9 @@ By installing this extension, you are agreeing to the Google Widevine Terms of U
       <message name="IDS_SETTINGS_IPFS_ERROR_INVALID_ADDRESS" desc="The error message used when user input an invalid gateway address">
         Invalid gateway address
       </message>
+      <message name="IDS_SETTINGS_IPFS_ERROR_INVALID_ADDRESS_ORIGIN_ISOLATION" desc="The error message used when user input an invalid gateway address without origin isolation">
+        Only a valid IPFS gateway with Origin isolation enabled can be used in Brave
+      </message>
       <message name="IDS_SETTINGS_IPFS_AUTO_FALLBACK_TO_GATEWAY_LABEL" desc="The text label for IPFS public gateway fallback switch">
         IPFS public gateway fallback
       </message>
diff --git a/browser/resources/settings/brave_ipfs_page/change_ipfs_gateway_dialog.html b/browser/resources/settings/brave_ipfs_page/change_ipfs_gateway_dialog.html
index a1508aa643d..71166e4a65b 100644
--- a/browser/resources/settings/brave_ipfs_page/change_ipfs_gateway_dialog.html
+++ b/browser/resources/settings/brave_ipfs_page/change_ipfs_gateway_dialog.html
@@ -6,7 +6,7 @@
     <cr-input id="url" label="$i18n{changeIpfsGatewayDialogLabel}"
         type="url" placeholder="https://dweb.link"
         invalid="[[!isUrlValid_]]"
-        error-message="$i18n{ipfsErrorInvalidAddress}" spellcheck="false"
+        error-message="[[invalidAddressMessage_]]" spellcheck="false"
         on-input=urlChanged_
         autofocus>
     </cr-input>
diff --git a/browser/resources/settings/brave_ipfs_page/change_ipfs_gateway_dialog.js b/browser/resources/settings/brave_ipfs_page/change_ipfs_gateway_dialog.js
index 1a0ab7e9a77..0c8fa8ba823 100644
--- a/browser/resources/settings/brave_ipfs_page/change_ipfs_gateway_dialog.js
+++ b/browser/resources/settings/brave_ipfs_page/change_ipfs_gateway_dialog.js
@@ -43,11 +43,14 @@ Polymer({
      * @private
      */
     gatewayUrl_: String,
+
+    invalidAddressMessage_: String
   },
   browserProxy_: null,
   /** @override */
   created: function() {
     this.browserProxy_ = BraveIPFSBrowserProxyImpl.getInstance();
+    this.invalidAddressMessage_ = this.i18n('ipfsErrorInvalidAddress')
   },
 
   /** @override */
@@ -65,7 +68,7 @@ Polymer({
       this.isSubmitButtonEnabled_ = false;
       return;
     }
-
+    this.invalidAddressMessage_ = this.i18n('ipfsErrorInvalidAddress')
     let url;
     try {
       url = new URL(url_.trim());
@@ -90,6 +93,8 @@ Polymer({
       if (success) {
         this.setPrefValue('brave.ipfs.public_gateway_address', this.gatewayUrl_);
         this.fire('close');
+      } else {
+        this.invalidAddressMessage_ = this.i18n('ipfsErrorInvalidAddressOrigin')
       }
     });
   },
diff --git a/chromium_src/chrome/browser/ui/webui/settings/settings_localized_strings_provider.cc b/chromium_src/chrome/browser/ui/webui/settings/settings_localized_strings_provider.cc
index 83ff01793ad..47ce53d1f0b 100644
--- a/chromium_src/chrome/browser/ui/webui/settings/settings_localized_strings_provider.cc
+++ b/chromium_src/chrome/browser/ui/webui/settings/settings_localized_strings_provider.cc
@@ -262,6 +262,8 @@ void BraveAddCommonStrings(content::WebUIDataSource* html_source,
     {"changeIpfsStorageMaxLabel", IDS_SETTINGS_CHANGE_IPFS_STORAGE_MAX_LABEL},
     {"changeIpfsStorageMaxDesc", IDS_SETTINGS_CHANGE_IPFS_STORAGE_MAX_DESC},
     {"ipfsErrorInvalidAddress", IDS_SETTINGS_IPFS_ERROR_INVALID_ADDRESS},
+    {"ipfsErrorInvalidAddressOrigin",
+     IDS_SETTINGS_IPFS_ERROR_INVALID_ADDRESS_ORIGIN_ISOLATION},
     {"ipfsAutoFallbackToGatewayLabel",
      IDS_SETTINGS_IPFS_AUTO_FALLBACK_TO_GATEWAY_LABEL},
     {"ipfsAutoFallbackToGatewayDesc",