diff --git a/browser/brave_profile_prefs.cc b/browser/brave_profile_prefs.cc
index 25290400fb6..d42a69a0ea8 100644
--- a/browser/brave_profile_prefs.cc
+++ b/browser/brave_profile_prefs.cc
@@ -165,6 +165,27 @@ void RegisterProfilePrefsForMigration(
   registry->RegisterBooleanPref(kDontAskEnableWebDiscovery, false);
   registry->RegisterIntegerPref(kBraveSearchVisitCount, 0);
 #endif
+
+  // Added 24/11/2022: https://github.com/brave/brave-core/pull/16027
+#if !BUILDFLAG(IS_IOS) && !BUILDFLAG(IS_ANDROID)
+  registry->RegisterStringPref(kFTXAccessToken, "");
+  registry->RegisterStringPref(kFTXOauthHost, "");
+  registry->RegisterBooleanPref(kFTXNewTabPageShowFTX, false);
+  registry->RegisterBooleanPref(kCryptoDotComNewTabPageShowCryptoDotCom, false);
+  registry->RegisterBooleanPref(kCryptoDotComHasBoughtCrypto, false);
+  registry->RegisterBooleanPref(kCryptoDotComHasInteracted, false);
+  registry->RegisterStringPref(kGeminiAccessToken, "");
+  registry->RegisterStringPref(kGeminiRefreshToken, "");
+  registry->RegisterBooleanPref(kNewTabPageShowGemini, false);
+#endif
+
+  // Added 24/11/2022: https://github.com/brave/brave-core/pull/16027
+#if !BUILDFLAG(IS_IOS)
+  registry->RegisterStringPref(kBinanceAccessToken, "");
+  registry->RegisterStringPref(kBinanceRefreshToken, "");
+  registry->RegisterBooleanPref(kNewTabPageShowBinance, false);
+  registry->RegisterBooleanPref(kBraveSuggestedSiteSuggestionsEnabled, false);
+#endif
 }
 
 void RegisterProfilePrefs(user_prefs::PrefRegistrySyncable* registry) {
diff --git a/chromium_src/chrome/browser/prefs/browser_prefs.cc b/chromium_src/chrome/browser/prefs/browser_prefs.cc
index fd916f2f452..c20038d2efa 100644
--- a/chromium_src/chrome/browser/prefs/browser_prefs.cc
+++ b/chromium_src/chrome/browser/prefs/browser_prefs.cc
@@ -118,6 +118,27 @@ void MigrateObsoleteProfilePrefs(Profile* profile) {
 #if BUILDFLAG(ENABLE_CUSTOM_BACKGROUND)
   NTPBackgroundPrefs(profile->GetPrefs()).MigrateOldPref();
 #endif
+
+  // Added 24/11/2022: https://github.com/brave/brave-core/pull/16027
+#if !BUILDFLAG(IS_IOS) && !BUILDFLAG(IS_ANDROID)
+  profile->GetPrefs()->ClearPref(kFTXAccessToken);
+  profile->GetPrefs()->ClearPref(kFTXOauthHost);
+  profile->GetPrefs()->ClearPref(kFTXNewTabPageShowFTX);
+  profile->GetPrefs()->ClearPref(kCryptoDotComNewTabPageShowCryptoDotCom);
+  profile->GetPrefs()->ClearPref(kCryptoDotComHasBoughtCrypto);
+  profile->GetPrefs()->ClearPref(kCryptoDotComHasInteracted);
+  profile->GetPrefs()->ClearPref(kGeminiAccessToken);
+  profile->GetPrefs()->ClearPref(kGeminiRefreshToken);
+  profile->GetPrefs()->ClearPref(kNewTabPageShowGemini);
+#endif
+
+  // Added 24/11/2022: https://github.com/brave/brave-core/pull/16027
+#if !BUILDFLAG(IS_IOS)
+  profile->GetPrefs()->ClearPref(kBinanceAccessToken);
+  profile->GetPrefs()->ClearPref(kBinanceRefreshToken);
+  profile->GetPrefs()->ClearPref(kNewTabPageShowBinance);
+  profile->GetPrefs()->ClearPref(kBraveSuggestedSiteSuggestionsEnabled);
+#endif
   // END_MIGRATE_OBSOLETE_PROFILE_PREFS
 }
 
diff --git a/components/constants/pref_names.h b/components/constants/pref_names.h
index 30c85e4e617..8c7fe6cbf66 100644
--- a/components/constants/pref_names.h
+++ b/components/constants/pref_names.h
@@ -92,4 +92,28 @@ extern const char kDontAskForCrashReporting[];
 // kEnableMediaRouterOnRestart on restart.
 extern const char kEnableMediaRouterOnRestart[];
 
+// Obsolete widget removal prefs
+#if !BUILDFLAG(IS_IOS) && !BUILDFLAG(IS_ANDROID)
+constexpr char kFTXAccessToken[] = "brave.ftx.access_token";
+constexpr char kFTXOauthHost[] = "brave.ftx.oauth_host";
+constexpr char kFTXNewTabPageShowFTX[] = "ftx.new_tab_page.show_ftx";
+constexpr char kCryptoDotComNewTabPageShowCryptoDotCom[] =
+    "crypto_dot_com.new_tab_page.show_crypto_dot_com";
+constexpr char kCryptoDotComHasBoughtCrypto[] =
+    "crypto_dot_com.new_tab_page.has_bought_crypto";
+constexpr char kCryptoDotComHasInteracted[] =
+    "crypto_dot_com.new_tab_page.has_interacted";
+constexpr char kGeminiAccessToken[] = "brave.gemini.access_token";
+constexpr char kGeminiRefreshToken[] = "brave.gemini.refresh_token";
+constexpr char kNewTabPageShowGemini[] = "brave.new_tab_page.show_gemini";
+#endif
+
+#if !BUILDFLAG(IS_IOS)
+constexpr char kBinanceAccessToken[] = "brave.binance.access_token";
+constexpr char kBinanceRefreshToken[] = "brave.binance.refresh_token";
+constexpr char kNewTabPageShowBinance[] = "brave.new_tab_page.show_binance";
+constexpr char kBraveSuggestedSiteSuggestionsEnabled[] =
+    "brave.brave_suggested_site_suggestions_enabled";
+#endif
+
 #endif  // BRAVE_COMPONENTS_CONSTANTS_PREF_NAMES_H_