diff --git a/changes/39987-clarify-not-supported-tooltips b/changes/39987-clarify-not-supported-tooltips
new file mode 100644
index 0000000000..08ae8c07fb
--- /dev/null
+++ b/changes/39987-clarify-not-supported-tooltips
@@ -0,0 +1,4 @@
+- Added tooltips to the "Agent", "Last restarted", and "Status" column headers on the Hosts page explaining which platforms are supported and why.
+- Fixed the "Last restarted" vital showing on ChromeOS hosts, where it's not actually collected.
+- Updated the "Last opened" tooltip on the Host details Software table to explain why it's only supported for native macOS, Windows, and Linux apps and packages.
+- Removed the `cellProps.rows.length === 1` workaround (which suppressed the tooltip whenever the table had exactly one row) by adding the correct CSS, which removes the tooltip overflowing if the host table is only 1 row.
diff --git a/frontend/pages/hosts/ManageHostsPage/HostTableConfig.tsx b/frontend/pages/hosts/ManageHostsPage/HostTableConfig.tsx
index 677e3b622c..0a2ad02a7e 100644
--- a/frontend/pages/hosts/ManageHostsPage/HostTableConfig.tsx
+++ b/frontend/pages/hosts/ManageHostsPage/HostTableConfig.tsx
@@ -397,26 +397,23 @@ const allHostTableHeaders = (teamId?: number): IHostTableColumnConfig[] => [
   // Status
   {
     title: "Status",
-    Header: (cellProps: IHostTableHeaderProps) => {
+    Header: () => {
       const titleWithToolTip = (
         <TooltipWrapper
           tipContent={
             <>
-              Online hosts will respond to a live report. Currently only
-              supported for macOS, Windows, and Linux.
+              Only supported on hosts that run Fleet&apos;s agent: macOS,
+              Windows, Linux, and ChromeOS.
             </>
           }
           className="status-header"
+          tooltipClass="host-table-header-tooltip"
+          fixedPositionStrategy
         >
           Status
         </TooltipWrapper>
       );
-      return (
-        <HeaderCell
-          value={cellProps.rows.length === 1 ? "Status" : titleWithToolTip}
-          disableSortBy
-        />
-      );
+      return <HeaderCell value={titleWithToolTip} disableSortBy />;
     },
     disableSortBy: true,
     accessor: "status",
@@ -592,9 +589,23 @@ const allHostTableHeaders = (teamId?: number): IHostTableColumnConfig[] => [
   // Agent
   {
     title: "Agent",
-    Header: (cellProps: IHostTableHeaderProps) => (
-      <HeaderCell value="Agent" isSortedDesc={cellProps.column.isSortedDesc} />
-    ),
+    Header: (cellProps: IHostTableHeaderProps) => {
+      const titleWithToolTip = (
+        <TooltipWrapper
+          tipContent="Only supported on hosts that run Fleet's agent: macOS, Windows, Linux, and ChromeOS."
+          tooltipClass="host-table-header-tooltip"
+          fixedPositionStrategy
+        >
+          Agent
+        </TooltipWrapper>
+      );
+      return (
+        <HeaderCell
+          value={titleWithToolTip}
+          isSortedDesc={cellProps.column.isSortedDesc}
+        />
+      );
+    },
     accessor: (row) => row.orbit_version || row.osquery_version,
     id: "agent",
     Cell: (cellProps: IHostTableStringCellProps) => {
@@ -686,12 +697,23 @@ const allHostTableHeaders = (teamId?: number): IHostTableColumnConfig[] => [
   // Last restarted
   {
     title: "Last restarted",
-    Header: (cellProps: IHostTableHeaderProps) => (
-      <HeaderCell
-        value="Last restarted"
-        isSortedDesc={cellProps.column.isSortedDesc}
-      />
-    ),
+    Header: (cellProps: IHostTableHeaderProps) => {
+      const titleWithToolTip = (
+        <TooltipWrapper
+          tipContent="Only supported on macOS, Windows, and Linux, where Fleet's agent can measure system uptime."
+          tooltipClass="host-table-header-tooltip"
+          fixedPositionStrategy
+        >
+          Last restarted
+        </TooltipWrapper>
+      );
+      return (
+        <HeaderCell
+          value={titleWithToolTip}
+          isSortedDesc={cellProps.column.isSortedDesc}
+        />
+      );
+    },
     accessor: "last_restarted_at",
     id: "last_restarted_at",
     Cell: (cellProps: IHostTableStringCellProps) => {
diff --git a/frontend/pages/hosts/ManageHostsPage/_styles.scss b/frontend/pages/hosts/ManageHostsPage/_styles.scss
index fa50d2cdab..049b5f6fd7 100644
--- a/frontend/pages/hosts/ManageHostsPage/_styles.scss
+++ b/frontend/pages/hosts/ManageHostsPage/_styles.scss
@@ -251,3 +251,9 @@
     padding-bottom: $pad-large;
   }
 }
+
+// The tooltip renders in a portal outside .manage-hosts, so this can't be
+// nested under that selector.
+.host-table-header-tooltip {
+  text-align: left;
+}
diff --git a/frontend/pages/hosts/details/cards/Software/HostSoftware.tsx b/frontend/pages/hosts/details/cards/Software/HostSoftware.tsx
index 69e1e1ba9a..5945428274 100644
--- a/frontend/pages/hosts/details/cards/Software/HostSoftware.tsx
+++ b/frontend/pages/hosts/details/cards/Software/HostSoftware.tsx
@@ -305,9 +305,8 @@ const HostSoftware = ({
           router,
           teamId: hostTeamId,
           onShowInventoryVersions,
-          platform,
         });
-  }, [isMyDevicePage, router, hostTeamId, onShowInventoryVersions, platform]);
+  }, [isMyDevicePage, router, hostTeamId, onShowInventoryVersions]);
 
   const isLoading = isMyDevicePage
     ? deviceSoftwareLoading
diff --git a/frontend/pages/hosts/details/cards/Software/HostSoftwareTableConfig.tests.tsx b/frontend/pages/hosts/details/cards/Software/HostSoftwareTableConfig.tests.tsx
index c7e27a2891..a5cb2f2649 100644
--- a/frontend/pages/hosts/details/cards/Software/HostSoftwareTableConfig.tests.tsx
+++ b/frontend/pages/hosts/details/cards/Software/HostSoftwareTableConfig.tests.tsx
@@ -13,7 +13,6 @@ describe("HostSoftwareTableConfig - Last opened column", () => {
     router: mockRouter,
     teamId: 1,
     onShowInventoryVersions: noop,
-    platform: "windows",
   });
 
   const lastOpenedColumn = headers.find((h) => h.id === "Last opened") as any;
diff --git a/frontend/pages/hosts/details/cards/Software/HostSoftwareTableConfig.tsx b/frontend/pages/hosts/details/cards/Software/HostSoftwareTableConfig.tsx
index ab2ae305a7..e5b09ea873 100644
--- a/frontend/pages/hosts/details/cards/Software/HostSoftwareTableConfig.tsx
+++ b/frontend/pages/hosts/details/cards/Software/HostSoftwareTableConfig.tsx
@@ -7,13 +7,6 @@ import {
   IHostSoftware,
   isIpadOrIphoneSoftwareSource,
 } from "interfaces/software";
-import {
-  HostPlatform,
-  isIPadOrIPhone,
-  isLinuxLike,
-  isMacOS,
-  isWindows,
-} from "interfaces/platform";
 import { IHeaderProps, IStringCellProps } from "interfaces/datatable_config";
 
 import PATHS from "router/paths";
@@ -47,7 +40,6 @@ interface ISoftwareTableHeadersProps {
   router: InjectedRouter;
   teamId: number;
   onShowInventoryVersions: (software: IHostSoftware) => void;
-  platform: HostPlatform;
 }
 
 // NOTE: cellProps come from react-table
@@ -56,7 +48,6 @@ export const generateSoftwareTableHeaders = ({
   router,
   teamId,
   onShowInventoryVersions,
-  platform,
 }: ISoftwareTableHeadersProps): ISoftwareTableConfig[] => {
   const tableHeaders: ISoftwareTableConfig[] = [
     {
@@ -132,24 +123,18 @@ export const generateSoftwareTableHeaders = ({
     },
     {
       Header: (): JSX.Element => {
-        let tooltipContent = <></>;
-
-        if (isMacOS(platform)) {
-          tooltipContent = (
-            <>When the version installed most recently was last opened.</>
-          );
-        } else if (isLinuxLike(platform) || isWindows(platform)) {
-          tooltipContent = <>When any version was last opened.</>;
-        } else if (isIPadOrIPhone(platform)) {
-          tooltipContent = <>Date and time of last open.</>;
-        }
-
-        const lastOpenedHeader = tooltipContent ? (
-          <TooltipWrapper tipContent={tooltipContent}>
+        const lastOpenedHeader = (
+          <TooltipWrapper
+            tipContent={
+              <>
+                Only supported for macOS, Windows, and Linux native apps and
+                packages. Browser extensions, other package managers, and mobile
+                apps don&apos;t report this information.
+              </>
+            }
+          >
             Last opened
           </TooltipWrapper>
-        ) : (
-          "Last opened"
         );
         return <HeaderCell value={lastOpenedHeader} disableSortBy />;
       },
diff --git a/frontend/pages/hosts/details/cards/Vitals/Vitals.tests.tsx b/frontend/pages/hosts/details/cards/Vitals/Vitals.tests.tsx
index ca1fc88f57..f3125aed96 100644
--- a/frontend/pages/hosts/details/cards/Vitals/Vitals.tests.tsx
+++ b/frontend/pages/hosts/details/cards/Vitals/Vitals.tests.tsx
@@ -4,6 +4,7 @@ import { createCustomRenderer } from "test/test-utils";
 
 import createMockHost, { createMockHostGeolocation } from "__mocks__/hostMock";
 import { createMockHostMdmData } from "__mocks__/mdmMock";
+import { HostPlatform } from "interfaces/platform";
 
 import { DEFAULT_EMPTY_CELL_VALUE } from "utilities/constants";
 import Vitals from "./Vitals";
@@ -578,6 +579,47 @@ describe("Agent data", () => {
   });
 });
 
+describe("Last restarted vital", () => {
+  it.each(["darwin", "windows", "ubuntu"])(
+    "renders Last restarted for supported platform: %s",
+    (platform) => {
+      const mockHost = createMockHost({
+        platform: platform as HostPlatform,
+        last_restarted_at: "2023-01-01T00:00:00Z",
+      });
+
+      render(<Vitals vitalsData={mockHost} />);
+
+      expect(screen.getByText("Last restarted")).toBeInTheDocument();
+    }
+  );
+
+  it.each(["chrome", "ios", "ipados", "android"])(
+    "does not render Last restarted for unsupported platform: %s",
+    (platform) => {
+      const mockHost = createMockHost({
+        platform: platform as HostPlatform,
+        last_restarted_at: "2023-01-01T00:00:00Z",
+      });
+
+      render(<Vitals vitalsData={mockHost} />);
+
+      expect(screen.queryByText("Last restarted")).not.toBeInTheDocument();
+    }
+  );
+});
+
+describe("Munki version vital", () => {
+  it("renders the Munki version vital when its value is a normal version string", () => {
+    const mockHost = createMockHost({ platform: "darwin" });
+
+    render(<Vitals vitalsData={mockHost} munki={{ version: "5.5.1" }} />);
+
+    expect(screen.getByText("Munki version")).toBeInTheDocument();
+    expect(screen.getByText("5.5.1")).toBeInTheDocument();
+  });
+});
+
 describe("Disk space field visibility", () => {
   it("hides disk space field when storage measurement is not supported (sentinel value -1)", () => {
     const mockHost = createMockHost({
diff --git a/frontend/pages/hosts/details/cards/Vitals/Vitals.tsx b/frontend/pages/hosts/details/cards/Vitals/Vitals.tsx
index 24ef40b03d..8bd898dbf0 100644
--- a/frontend/pages/hosts/details/cards/Vitals/Vitals.tsx
+++ b/frontend/pages/hosts/details/cards/Vitals/Vitals.tsx
@@ -371,7 +371,7 @@ const Vitals = ({
     });
 
     // Last restarted
-    if (!isIosOrIpadosHost && !isAndroidHost) {
+    if (!isIosOrIpadosHost && !isAndroidHost && !isChromeHost) {
       vitals.push({
         sortKey: "Last restarted",
         element: (