diff --git a/changes/issue-5595-duplicate-hosts-vuln-webhook b/changes/issue-5595-duplicate-hosts-vuln-webhook
new file mode 100644
index 0000000000..8d059a2800
--- /dev/null
+++ b/changes/issue-5595-duplicate-hosts-vuln-webhook
@@ -0,0 +1 @@
+* Fixed an issue with duplicated hosts being sent in the vulnerability webhook payload.
diff --git a/server/datastore/mysql/software.go b/server/datastore/mysql/software.go
index 856048635d..6b349a7018 100644
--- a/server/datastore/mysql/software.go
+++ b/server/datastore/mysql/software.go
@@ -976,7 +976,7 @@ func (ds *Datastore) CalculateHostsPerSoftware(ctx context.Context, updatedAt ti
 // matching hosts.
 func (ds *Datastore) HostsByCPEs(ctx context.Context, cpes []string) ([]*fleet.HostShort, error) {
 	queryStmt := `
-    SELECT
+    SELECT DISTINCT
       h.id,
       h.hostname
     FROM
diff --git a/server/datastore/mysql/software_test.go b/server/datastore/mysql/software_test.go
index 4a69738a37..0b92f31c0c 100644
--- a/server/datastore/mysql/software_test.go
+++ b/server/datastore/mysql/software_test.go
@@ -36,6 +36,7 @@ func TestSoftware(t *testing.T) {
 		{"ListVulnerableSoftwareBySource", testListVulnerableSoftwareBySource},
 		{"DeleteVulnerabilitiesByCPECVE", testDeleteVulnerabilitiesByCPECVE},
 		{"HostsByCVE", testHostsByCVE},
+		{"HostsByCPEs", testHostsByCPEs},
 		{"UpdateHostSoftware", testUpdateHostSoftware},
 		{"ListSoftwareByHostIDShort", testListSoftwareByHostIDShort},
 	}
@@ -1170,6 +1171,34 @@ func testHostsByCVE(t *testing.T, ds *Datastore) {
 	require.Equal(t, hosts[0].Hostname, "host2")
 }
 
+func testHostsByCPEs(t *testing.T, ds *Datastore) {
+	ctx := context.Background()
+
+	hosts, err := ds.HostsByCPEs(ctx, []string{"cpe_foo_chrome_3"})
+	require.NoError(t, err)
+	require.Len(t, hosts, 0)
+
+	insertVulnSoftwareForTest(t, ds)
+
+	hosts, err = ds.HostsByCPEs(ctx, []string{"cpe_foo_chrome_3"})
+	require.NoError(t, err)
+	require.Len(t, hosts, 2)
+	require.Equal(t, hosts[0].Hostname, "host1")
+	require.Equal(t, hosts[1].Hostname, "host2")
+
+	hosts, err = ds.HostsByCPEs(ctx, []string{"cpe_bar_rpm"})
+	require.NoError(t, err)
+	require.Len(t, hosts, 1)
+	require.Equal(t, hosts[0].Hostname, "host2")
+
+	// Duplicates should not be returned if cpes are found on the same host ie host2 should only appear once
+	hosts, err = ds.HostsByCPEs(ctx, []string{"cpe_foo_chrome_3", "cpe_bar_rpm"})
+	require.NoError(t, err)
+	require.Len(t, hosts, 2)
+	require.Equal(t, hosts[0].Hostname, "host1")
+	require.Equal(t, hosts[1].Hostname, "host2")
+}
+
 func testUpdateHostSoftware(t *testing.T, ds *Datastore) {
 	ctx := context.Background()