diff --git a/changes/35192-imp-correct-classification b/changes/35192-imp-correct-classification
new file mode 100644
index 0000000000..5144468e8a
--- /dev/null
+++ b/changes/35192-imp-correct-classification
@@ -0,0 +1 @@
+* Differentiated IMP and Integrative Modeling Platform (IMP) while running vulnerability scanning.
\ No newline at end of file
diff --git a/server/vulnerabilities/nvd/cpe.go b/server/vulnerabilities/nvd/cpe.go
index 3d64c5f94b..7de65280b7 100644
--- a/server/vulnerabilities/nvd/cpe.go
+++ b/server/vulnerabilities/nvd/cpe.go
@@ -395,6 +395,17 @@ var (
 				s.Version = newVersion
 			},
 		},
+		{
+			// Homebrew's "imp" (Integrative Modeling Platform) is incorrectly matched against
+			// Horde IMP CPEs. Rename the Homebrew package to prevent incorrect CPE
+			// matching with horde:imp.
+			matches: func(s *fleet.Software) bool {
+				return s.Name == "imp" && s.Source == "homebrew_packages"
+			},
+			mutate: func(s *fleet.Software, logger log.Logger) {
+				s.Name = "integrative-modeling-platform"
+			},
+		},
 	}
 )
 
diff --git a/server/vulnerabilities/nvd/cpe_test.go b/server/vulnerabilities/nvd/cpe_test.go
index 73d87dc7c8..5d5a284e69 100644
--- a/server/vulnerabilities/nvd/cpe_test.go
+++ b/server/vulnerabilities/nvd/cpe_test.go
@@ -2316,6 +2316,45 @@ func TestMutateSoftware(t *testing.T) {
 				Source:  "programs",
 			},
 		},
+		{
+			name: "Homebrew imp (Integrative Modeling Platform)",
+			s: &fleet.Software{
+				Name:    "imp",
+				Version: "2.23.0_13",
+				Source:  "homebrew_packages",
+			},
+			sanitized: &fleet.Software{
+				Name:    "integrative-modeling-platform",
+				Version: "2.23.0_13",
+				Source:  "homebrew_packages",
+			},
+		},
+		{
+			name: "imp from non-Homebrew source (should not be renamed)",
+			s: &fleet.Software{
+				Name:    "imp",
+				Version: "5.0.22",
+				Source:  "programs",
+			},
+			sanitized: &fleet.Software{
+				Name:    "imp",
+				Version: "5.0.22",
+				Source:  "programs",
+			},
+		},
+		{
+			name: "Homebrew imp with different version",
+			s: &fleet.Software{
+				Name:    "imp",
+				Version: "2.20.0",
+				Source:  "homebrew_packages",
+			},
+			sanitized: &fleet.Software{
+				Name:    "integrative-modeling-platform",
+				Version: "2.20.0",
+				Source:  "homebrew_packages",
+			},
+		},
 	} {
 		t.Run(tc.name, func(t *testing.T) {
 			require.NotPanics(t, func() { mutateSoftware(tc.s, log.NewNopLogger()) })