diff --git a/changes/27475-fix-query-page-selection-clear b/changes/27475-fix-query-page-selection-clear
new file mode 100644
index 0000000000..a950b929c1
--- /dev/null
+++ b/changes/27475-fix-query-page-selection-clear
@@ -0,0 +1 @@
+- Fixed an issue where selections made on the Queries page were cleared a few seconds after page load.
\ No newline at end of file
diff --git a/frontend/pages/queries/ManageQueriesPage/ManageQueriesPage.tsx b/frontend/pages/queries/ManageQueriesPage/ManageQueriesPage.tsx
index a407596d87..2c261ded04 100644
--- a/frontend/pages/queries/ManageQueriesPage/ManageQueriesPage.tsx
+++ b/frontend/pages/queries/ManageQueriesPage/ManageQueriesPage.tsx
@@ -1,4 +1,10 @@
-import React, { useContext, useCallback, useEffect, useState } from "react";
+import React, {
+  useContext,
+  useCallback,
+  useEffect,
+  useMemo,
+  useState,
+} from "react";
 import { InjectedRouter } from "react-router";
 import { useQuery } from "react-query";
 import { pick } from "lodash";
@@ -162,7 +168,10 @@ const ManageQueriesPage = ({
     }
   );
 
-  const enhancedQueries = queriesResponse?.queries.map(enhanceQuery);
+  // Enhance the queries from the response when they are changed.
+  const enhancedQueries = useMemo(() => {
+    return queriesResponse?.queries.map(enhanceQuery) || [];
+  }, [queriesResponse]);
 
   const queriesAvailableToAutomate =
     (teamIdForApi !== API_ALL_TEAMS_ID